Saddest moment for me as a Dreamer...well, to risk sounding redundant, the end of Destiny and EOTW were the only episodes that had me crying, but the conversation from the Harvest got me, when Liz is walking down the street.
MAX: Liz! Liz, what are you doing? We agreed none of us would go anywhere alone.
LIZ: Fine.
MAX: Wait.
LIZ: Max, look. There's just...there's nothing left to say.
MAX: Except the truth.
LIZ: We have already been through this!
MAX: So far, all I know is what I saw, and what I saw can't be true, because it means everything I felt in my heart for the last year is a lie! Now, you owe me an explanation, and I want it right now!
LIZ: Please quit shouting, Max. You're scaring me.
MAX: That's a lie, too! You're not scared. You're hiding something.
LIZ: I'm not.
MAX: What the hell is going on with you, Liz? We never lied to each other, never kept a secret from each other.
LIZ: You know, you have got me up on this pedestal, Max, and...I'm not this perfect person. I made a mistake. Look, Kyle and I made love. The end. I'm sorry.

just broke my little Dreamer heart. The way Max says "what the hell is going on with you, Liz?" always got to me. The whole conversation is just heartbreaking!!